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Blood transfusions used to be the treatment of last resort, since they often caused death. But in the 1890s Austrian scientist Karl Landsteiner began to solve the transfusion puzzle when he found that all human red blood cells belonged to one of four groups which he named A, B, AB, and O. The types refer to antigens found on the surface of these cells. Antibodies circulating in a person's blood normally recognize the antigens in that same person's blood cells and don't react with them. However, if a person with one blood type is transfused with blood of another type, the antibodies bind to the foreign antigens, causing dangerous clumping of the blood. Thus the key to a successful transfusion is to give a person blood that has matching antigens. In the first half of the twentieth century, the study of Rhesus monkeys, which share many biological characteristics with humans, gave rise to the recognition of a human blood protein called the Rh factor. People who have this blood protein are considered Rh positive, while individuals who lack the protein are referred to as Rh negative. The Rh factor is connected to an individual's blood type. If a person has type AB blood with a positive Rh factor, his or her blood type is referred to as AB positive. The Rh factor causes a problem in a fetus whose blood is Rh positive and whose mother is Rh negative because the mother's negative blood attacks the positive blood of the fetus. In this instance, a blood transfusion to the fetus can save its life.