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a military movement or advance all the way through and beyond an enemy's frontline defense.

an act or instance of removing or surpassing an obstruction or restriction; the overcoming of a stalemate.

any significant or sudden advance, development, achievement, or increase, as in scientific knowledge or diplomacy, that removes a barrier to progress.

Medicine/Medical.��an infection, disease, disorder, or condition that occurs in an individual despite their having received a vaccine, medication, or treatment.

constituting a breakthrough: Critics called it a breakthrough film.

Medicine/Medical.��relating to or being an infection, disease, disorder, or condition that occurs as a breakthrough: She experienced disabling breakthrough pain despite the high dose of painkillers she was taking.