51�Թ�

"The question we always ask is, can we exploit microbiota to help our health, for which optimal blood pressure is a cardinal sign. Until now, we have simply said changes in microbiota play a role in elevated blood pressure or hypertension. Those are important findings, but they don't always have an immediately translational application," she said.

Brain shrinkage is a cardinal sign of dementia and brain damage in general.

Libra, as a cardinal sign, is somewhat more stable.

Yet another cardinal sign of frailty is weight loss.

Social withdrawal is both a symptom of sickness behavior in rodents and a cardinal sign of depression in humans.