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Opioids prescribed at the lowest effective dose also make sense for some other patients who do not tolerate or benefit adequately from alternatives.

“With any drug, you want to use the lowest effective dose,” he said.

"What this suggests is that the lowest effective dose of docetaxel may be lower when the drug is combined with dicyclomine, compared to when docetaxel is used alone," Wu said.

It is not possible to calculate the effective dose of lignans in the diet from these enterolactone findings, because the gut microbiome that plays a role in metabolism of lignans varies among individuals.

And if they opt for HRT, use the lowest effective dose.