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"Overall, we're experiencing a huge, huge increase in desperation, in hopelessness and suicidal ideation."

Still, questions remain on how exactly antidepressants lift the symptoms of depression, which may include persistent feelings of hopelessness, low energy, and suicidal thoughts.

It pays tribute to the human ability to act with kindness toward others even when filled with hopelessness.

In this moment, I can't stress enough how difficult it is to move people from hopelessness and disappointment to excitement, and our campaign is doing that.

But such emotions can easily fuel hopelessness if people are constantly made aware of new and overwhelming threats that they feel powerless to address.