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“I think there’s probably a bunch of episodes this season that are going to be people’s favorite episodes that they have ever seen,” says Povenmire, who also voices the show’s inept nemesis Dr. Heinz Doofenshmirtz.

And polio, the fearsome nemesis of American families in the 1950s, from 16,300 to zero.

"It's a parable of excess, hubris, and then eventually nemesis."

A surprise cameo from Lizzo paid alms to their long friendship, and a bawdy slice of her verse from Drake’s “Rich Baby Daddy” proved she can own even a nemesis’ material with her charisma.

After years of trying to make it as an actor, Mazino got his breakout role in the 2023 limited series “Beef,” where he portrays a slacker who falls for his older brother’s road-rage nemesis.