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Perianal fistulae, abnormal connections between the anal canal and perianal skin, are a common complication of Crohn's disease that often result in painful abscesses and impact patients' quality of life.

Goldstein recommends using a formula that is pH-balanced and isotonic “so that it does not strip the lining of your rectum or anal canal and, in theory, will not alter your microbiome.”

“It’s not like getting a colonoscopy. The person doing the procedure is only going 5 to 7 centimeters into the anal canal. I think a lot of people avoid it because they’re afraid of pain or discomfort and are unaware that it’s minimally invasive.”

“We know that HPV infects cells that line the anal canal the same as it infects cells that line the cervix,” Dr. Stephen Abbott told me.

Similarly, the sixth episodes segments featuring Cain-N’Degeocello taking pregnancy empathy to new lows by enlisting a Las Vegas spiritual healer to assist with his imitation of a birthing experience via anal canal, or “terrorist terminator” Erran Morad’s pointless encounter with “Real Housewives of Orange County” stars Gretchen Rossi and Slade Smiley, indicate more about the limits of these character than about his targets.