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The results also suggest that in patients, treatment with 11beta compounds once every few months, or even once a year, could significantly delay disease progression, and thus avoid the need for continuous, burdensome antiproliferative therapies such as tolvaptan.

Riociguat is a soluble guanylate cyclase stimulator and is thought to have vasodilating, antiproliferative and antifibrotic effects.

Riociguat, a soluble guanylate cyclase stimulator under development by Bayer, is thought to have vasodilating, antiproliferative and antifibrotic effects.

It’s also possible that this research may have implications beyond PAH, since this pathway seems to have a general antiproliferative effect in vascular beds, according to Archer.

Commonly applied drug-eluting stents release antiproliferative or anti-inflammatory agents to reduce the incidence of in-stent stenosis.