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Thus, Briggs and King’s results demonstrated that the nuclei in blastomeres are not irreversibly changed with differentiation.

To determine the chromosome copy number, single or multiple blastomeres were biopsied from embryos at the cleavage stage and clumps of approximately five cells were microdissected from the trophectoderm of blastocysts.

DNA samples from 86 individual blastomeres representing different treatments and controls were sequenced using the MiSeq platform.

It has been established experimentally in several kinds of animals that early cleavage blastomeres when isolated can each develop into a complete individual.

The hollow globe or sphere formed by the arrangement of the blastomeres on the periphery of an impregnated ovum.