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"TSPO could be of relevance both for clinical studies on NPC as for clinical routine. PET imaging might be difficult with young patients, as they need to stay calm while in the scanner. But we showed that it is feasible with older individuals affected by NPC," says Prof. Matthias Brendel, a neuroimaging expert at LMU Hospital.

"Half of these study participants had abnormal amyloid results in their PET scans," says Brendel, "and so the CSF is not reliable enough here."

The study was initiated by Professor Matthias Brendel, Acting Director of the Department of Nuclear Medicine, Dr. Nicolai Franzmeier from the Institute for Stroke and Dementia Research, and Professor Günther Höglinger, Director of the Neurological Clinic -- all three of whom are also members of the SyNergy Cluster of Excellence.

"From medical and economic standpoints, therefore, it seems reasonable to give these patients a CSF analysis in the first instance unless there are specific medical reasons to indicate otherwise," says Brendel.

Bettina Brendel, whose mammoth, six-panel 1969 painting “Particles or Waves?” gave the show its title, attempts with mixed success to evoke the foundational duality’s puzzling contradictions, laying out a sequence of crosshatch marks, jagged stripes and swollen curves.