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At the end of the block, a decadelong vendor of Grand Central Market found its own brick-and-mortar location and is, like its former food-hall brethren, greatly affected by the week’s loss of business.

Soul & Smoke grew into three brick-and-mortar locations in Chicago, became a staple vendor at Soldier Field and Northwestern’s stadium, and launched a line of condiments.

Thousands of independent pharmacies have closed in recent years, leaving entire counties without a single brick-and-mortar store where patients can fill a prescription.

But in far-flung places such as Yosemite — with spotty internet and cell service, no instant Amazon delivery as well as few brick-and-mortar stores and pharmacies — they are a lifeline.

It hasn’t always been easy so far — the overhead of a brick-and-mortar store is new, and they haven’t yet developed the same sized clientele they have in Palm Springs.