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"People's initial reaction was, 'You want to do what to your espresso?'" says Dulbecco.

"What Brandy saw was that consumers were looking for this coffee with flavors adhered to the beans, which was not a great experience," Dulbecco says.

Dulbecco, who started at Torani in 1991 and was mentored by Brandenburg and Lucheta, says it was tough going to sell to cafes in those early days.

Career highlights: Executive director, American Society for Cell Biology; director, office of science policy, planning and communications, National Institutes of Health; director, laboratory of mammalian genetics, Dulbecco Telethon Institute.

Nobel laureate dies Virologist Renato Dulbecco, who shared the 1975 Nobel Prize in Physiology or Medicine, died on 19 February, aged 97.