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The US firm Eli Lilly makes the active pharmaceutical ingredients for its Zepbound and Mounjaro weight loss treatments near Kinsale in County Cork.

Both pharmaceutical companies involved, Eisai for lecanemab and Eli Lilly for donanemab, say they will appeal against the decision.

"If the system can't deliver scientific firsts to NHS patients, it is broken," said Chris Stokes, Eli Lilly's president and general manager of UK and Northern Europe.

Eli Lilly, the company behind donanemab, has already expressed its disappointment.

Other examples included Eli Roth’s “Hostel.”