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Estrange, alienate, disaffect share the sense of causing (someone) to turn away from a previously held state of affection, comradeship, or allegiance. Estrange often implies replacement of love or belonging by apathy or hostility: erstwhile lovers estranged by a misunderstanding. Alienate often calls attention to the cause of antagonism or separation: His inconsiderate behavior alienated both friends and family. Disaffect usually refers to relationships involving allegiance or loyalty rather than love or affection: disaffected workers, demoralized by ill-considered management policies.