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“The problem was, Shein and Temu became the fundamental leaders of fast fashion,” said Ilse Metchek, former president of the California Fashion Assn.

On Christmas Eve in New York City 13 years ago, the director and his wife, actor Ilse Salas, visited a Times Square multiplex.

Fred Segal also failed to amplify its online presence, which hurt the brand’s relevance, said Ilse Metchek, an industry analyst and former president of the California Fashion Assn.

Ilse Valenzuela, 35, was trying to make ends meet after the pandemic left her and her husband without jobs.

Their work is the result of a collaboration between the research groups of neuroscientist Ann Massie of the Laboratory of Neuro-Aging & Viro-Immunotherapy and pancreatic cancer expert Ilse Rooman of the Laboratory for Medical and Molecular Oncology.