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Dopamine plays a vital role in regulating the movement of the body, and so symptons can include involuntary shaking, slow movement, and stiff and inflexible muscles; as well as depression and anxiety.

Managers and board members of the two agencies said that the dispute persisted for years because of inflexible positions, but that negotiations over the last year made possible a comprehensive agreement.

The prince's team did so by arguing Ravec's policy had been overly rigid and inflexible.

It says 48% of black girls fall out of love with sport in their teens because of issues such as racism, misogyny and inflexible sporting structures.

The watchdog identified an "inflexible and indiscriminate" approach to the use of key fobs to control access to internal doors and gates, regardless of whether service users had capacity.