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This question takes on added salience with Israel's attack on Iran and the Islamists' fear that they are facing an irreversible defeat.

Producer Brian Eno cited “Fresh” as the pivotal and irreversible production moment when “the rhythm instruments, particularly the bass drum and bass, suddenly become the important instruments in the mix.”

Many researchers are concerned some forests, such as parts of the Amazon, may be approaching a "tipping point", beyond which they could fall into irreversible decline.

Stuart Waldman, president of the Valley Industry and Commerce Assn., offered an equally dire warning, saying the wage increases will cause “irreversible damage” to local tourism.

On Monday morning, the Vatican announced the 88-year-old pope had died of a stroke and “irreversible cardiocirculatory collapse,” according to the Vatican News, an official publication of the Vatican.