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As the parents of the family, Isaacs and Posey used thick North Carolina accents, which tended to slosh around some depending on how much booze and anti-anxiety medication were in play.

Prof John Isaacs, who has worked on the condition for 35 years and is leading the research, believes this could make it possible to "switch off" rheumatoid arthritis.

As Mr Isaacs tried to avoid being stabbed he came into contact with Ms Maximen, who fell to the ground, the jury was told.

Blake: I am sure there will be debate about the authenticity of Jason Isaacs’ accent, but I thought it was pretty good.

That tour, called Good Morning Gorgeous, was timed to her album of the same name, her first since she finalized her protracted divorce from record producer Kendu Isaacs.