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They found that these actions can all be traced back to metabolic dysregulation in a process within the B cells called oxidative phosphorylation, a type of mitochondrial respiration.

COX17 helps put together a crucial part of the energy-production process in mitochondria, called complex IV. This complex is vital for producing energy through oxidative phosphorylation in cells.

This difference can be used to predict a tumour’s response to inhibitors of oxidative phosphorylation.

After testing several compounds, they found one that stymies an enzyme necessary for oxidative phosphorylation.

This led us to hypothesize that factors that induce or maintain cancer-resistant cells in a non-proliferative, differentiated state that uses oxidative phosphorylation, could have the characteristics of tumour suppressors if expressed in a neoplastic setting.