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It is thought to work by targeting CAG repeats on the RNA strand produced by both the normal and faulty HTT genes, and tagging them for destruction by an enzyme called RNase H1.

In this case, the resulting DNA-mRNA complex summons a cutting enzyme, RNase H, that degrades the mRNA and prevents its translation into protein.

HIV-1 reverse transcriptase-associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA.

This oligonucleotide directed RNase H cleavage, thereby generating 3′-terminal mRNA fragments with lengths suitable for high-resolution analysis on RNA blots.

This oligonucleotide directed RNase H cleavage, thereby generating 3′-terminal mRNA fragments with lengths suitable for high-resolution analysis on RNA blots.