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Having lost Kostantinos Mavropanos in the first leg, another central defender picked up an injury in this one as Nayef Aguerd stretched to win possession off Patrik Schick.

The 38-year-old keeper got down well to deny Patrick Schick in the first half before leaping to tip the striker's header over the bar in the second when he looked to have been wrong-footed.

The hosts' comeback was completed with a 91st-minute Patrik Schick winner.

Adam Hlozek and Patrik Schick scored either side of half-time to give the league leaders a two-goal cushion, with Yannik Keitel claiming a consolation.

West Ham ran out 5-0 winners against Freiburg to send them out of the competition, but Leverkusen reached the quarter-finals as two injury-time goals from Schick sealed a dramatic 5-4 aggregate victory against Qarabag.