51�Թ�

Metformin reduced the risk of dying from heart attack and stroke by about 30 percent to 40 percent compared with other commonly used drugs called sulfonylureas, such as glibenclamide, glimepiride, glipizide and tolbutamide, researchers report.

The headline appeared almost exactly 35 years ago, on July 4, 1975, about a different drug for Type 2 diabetes that went through a strikingly similar controversy: tolbutamide.